Cat#:PA-2984F;Product Name:Sheep Anti-Human Factor V Antibody, Biotin-Conjugation;Synonym:F5; factor five; coagulation factor V (proaccelerin, labile factor); FVL; PCCF; coagulation factor V; factor V Leiden; proaccelerin, labile factor; activated protein c cofactor; coagulation factor V jinjiang A2 domain; OTTHUMP00000032547; OTTHUMP00000032548; Factor V; FV;Background:Factor V (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320 kDa) that is produced in the liver. The gene that encodes factor V (FV) is located on chromosome 1. A congenital deficiency of FV is a hemorrhagic disorder inherited as an autosomal recessive disease. The concentration of FV in plasma is typically 10 μg/mL. FV is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface. Other physiologic activators of FV include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (FVa) is an essential component of the prothrombin activator complex, which consists of FVa, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more FV to FVa. Thrombin also acts to down-regulate FVa indirectly by activating Protein C, which inactivates FVa cofactor activity.;Description:Sheep Anti-Human Factor V Polyclonal Antibody, Biotin-Conjugation;Host Species:Sheep;Species Reactivity:Human;Isotype:IgG;Application:IEP, ELISA.;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;