Cat#:PA-2966F;Product Name:Sheep Anti-Bovine Coagulation Factor V Antibody;Synonym:F5; Factor V; F.V; Activated protein C cofactor; Coagulation factor V; Factor V Leiden; FactorV; FVL; Labile factor; coagulation factor V (proaccelerin, labile factor);Background:Factor V (formerly referred to as accelerator globulin and labile factor) is a large single chain glycoprotein (330 kDa) that is produced in the liver. The concentration of F.V in bovine plasma is approximately 35 μg/ml. F.V is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface. Other physiologic activators of F.V include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (F.Va) is an essential component of the prothrombin activator complex, which consists of F.Va, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more F.V to F.Va. Thrombin also acts to downregulate F.Va indirectly by activating Protein C, which inactivates F.Va cofactor activity.;Description:Sheep Anti-Bovine Coagulation Factor V Polyclonal Antibody;Host Species:Sheep;Species Reactivity:Bovine;Isotype:IgG;Application:IEP, ELISA;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;