Cat#:PA-3035F;Product Name:Rat Anti-Mouse Factor X Antibody;Synonym:fX; Cf10; F10; coagulation factor X; coagulation factor X; stuart factor; OTTMUSP00000022499; TTMUSP00000022500; OTTMUSP00000022651; OTTMUSP00000043610;Background:Factor X, also known by the eponym Stuart-Prower factor or as prothrombinase, is an enzyme (EC 3.4.21.6) of the coagulation cascade. It is a serine endopeptidase. Factor X is synthesized in the liver and requires vitamin K for its synthesis. Factor X is activated into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Xase). It is therefore the first member of the final common pathway or thrombin pathway. It acts by cleaving prothrombin in two places (an arg-thr and then an arg-ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex. Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis.;Description:Rat Anti-Mouse Factor X Monoclonal Antibody;Host Species:Rat;Species Reactivity:mouse;Clone#:AMX-9061;Isotype:N/A;Application:WB, ELA;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;