Cat#:PA-1138F;Product Name:Rabbit Anti-NKX3-1 (NKX3.1) Antibody;Synonym:NKX3-1; NK3 homeobox 1; NKX3; BAPX2; NKX3A; NKX3.1; homeobox protein Nkx-3.1; NK homeobox, family 3, A; homeobox protein NK-3 homolog A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; OTTHUMP00000123534; NK homeobox (Drosophila), family 3, A; NK3 transcription factor related, locus 1 (Drosophila);Background:NKX-3.1 is a protein found in humans and is encoded by the NKX3-1 gene located on chromosome 8. The homeodomain containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. NKX3.1 protein has been found to be positive in the vast majority of primary prostatic adenocarcinomas. A recent study showed that NKX3.1 staining was highly sensitive and specific for high-grade prostatic adenocarcinomas. The sensitivity for identifying metastatic prostatic adenocarcinomas overall was 98.6% (68/69 cases positive) for NKX3.1, and 94.2% (65/69 cores positive) for PSA. The specificity of NKX3.1 was 99.7% (1/349) in various cancers. NKX3.1 stains nuclei in both normal and prostate cancer; thus providing a robust stain that is easy-to-interpret, similar to other transcription factors such as TTF-1 or CDX2.;Description:Rabbit Anti-NKX3-1 (NKX3.1) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;