Cat#:PA-1336F;Product Name:Rabbit Anti-Mouse Mdm2 Antibody;Synonym:Mdm2; transformed mouse 3T3 cell double minute 2; Mdm-2; AA415488; 1700007J15Rik; E3 ubiquitin-protein ligase Mdm2; oncoprotein Mdm2; OTTMUSP00000022916; OTTMUSP00000022917; double minute 2 protein; p53-binding protein Mdm2;Background:This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.;Description:Rabbit Anti-Mouse Mdm2 Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Mouse;Isotype:N/A;Application:ELISA, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;