Cat#:FPA-21849P;Product Name:Rabbit Anti-IRG1 Polyclonal Antibody;Background:IRG1 (Immune-responsive gene 1) is one of the most up-regulated genes in macrophages under proinflammatory conditions. It is also highly expressed in the pregnant uterus during implantation. IRG1 is a cis-aconitate decarboxylase that produces itaconic acid by decarboxylating cis-aconic acid, an intermediate of the tricarboxylic acid cycle. Itaconic acid is an endogenous inhibitor of succinate dehydrogenase, linking macrophage metabolic rewiring and regulation of inflammation.;Description:Rabbit polyclonal antibody to IRG1. The rabbit anti IRG1 antibody was purified using our unique Immunogen affinity techniques;Source:Rabbit;Purity:Immunogen affinity purified;Host Species:Rabbit ;Immunogen:Synthetic peptide according to IRG1;Species Reactivity:Human;Isotype:IgG;Application:WB: 1/1000 - 1/3000. Predicted molecular weight: 53 kDa.;Positive control:WB: LoVo whole cell lysate.;Concentration:1 mg/ml ;Storage Buffer:pH: 7.40 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol, PBS, 0.87% Sodium chloride;Storage:Store rabbit IRG1 antibody at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Please avoid freeze / thaw cycle.;