Cat#:PA-136F;Product Name:Rabbit Anti-Human Ubiquitin Antibody;Synonym:UBB; ubiquitin B; UBC; UBA52; RPS27A; MGC8385; FLJ25987; polyubiquitin-B; polyubiquitin B; OTTHUMP00000064959;Background:Ubiquitin is a highly conserved 76 amino acid polypeptide with a central role in regulated protein degradation. The ubiquitin/proteasome pathway is the main non-lysosomal route for intracellular protein degradation in eukaryotes, and it plays a key role in many cellular processes, including cell-cycle progression, gene transcription, antigen processing and signal transduction. Proteins can be modified on lysine residues with single ubiquitin moieties, or be attached to branched multi-ubiquitin chains; the latter targets the proteins to the 26S proteasome: a complex, multicatalytic cytosolic and nuclear protease. Ubiquitin appears to be incorporated into inclusion bodies and protein accumulations characteristic of several of the major neurogenerative diseases including Alzheimer’s disease, Parkinson’s disease and Creutzfeldt Jakob disease. Recent findings also substantiate a role of the ubiquitin/proteasome pathway in the regulation of apoptosis.;Description:Rabbit Anti-Human Ubiquitin Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;