Cat#:PA-293F;Product Name:Rabbit Anti-Human TNFRSF14 (N-terminal) Antibody;Synonym:TNFRSF14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; CD40-like protein; OTTHUMP00000000866; OTTHUMP00000204095; OTTHUMP00000204096; OTTHUMP00000204097; herpesvirus entry mediator A; herpes virus entry mediator A; tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2;Background:TNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.;Description:Rabbit Anti-Human TNFRSF14 (N-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG2b;Application:WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;