Cat#:PA-502F;Product Name:Rabbit Anti-Human SOCS1 (C-terminal) Antibody;Synonym:SOCS1; suppressor of cytokine signaling 1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; Cish1; suppressor of cytokine signaling 1; TIP-3; OTTHUMP00000160221; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1;Background:This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.;Description:Rabbit Anti-Human SOCS1 (C-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG3;Application:WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;