Cat#:PA-1363F;Product Name:Rabbit Anti-Human MAVS (N-terminal) Antibody;Synonym:MAVS; mitochondrial antiviral signaling protein; IPS1; VISA; IPS-1; CARDIF; MGC3260; FLJ27482; FLJ31698; FLJ35386; FLJ38051; FLJ41962; KIAA1271; DKFZp547C224; DKFZp666M015; mitochondrial antiviral-signaling protein; OTTHUMP00000030141; IFN-B promoter stimulator 1; CARD adaptor inducing IFN-beta; virus-induced-signaling adapter; CARD adapter inducing interferon beta; mitochondrial anti-viral signaling protein; putative NF-kappa-B-activating protein 031N; interferon beta promoter stimulator protein 1;Background:Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1;Description:Rabbit Anti-Human MAVS (N-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:N/A;Application:IHC, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;