Cat#:PA-1296F;Product Name:Rabbit Anti-Human Matrix Metalloproteinase 9 Antibody;Synonym:MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; matrix metalloproteinase 9; type V collagenase; macrophage gelatinase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); EC 3.4.24.35; Matrix metalloproteinase-9; 92 kDa type IV collagenase; 92 kDa gelatinase; Gelatinase B; GELB; 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9; OTTHUMP00000031674; type V collagenase;Background:Matrix metalloproteinases (MMPs) comprise a family of structurally related zink-dependent endopeptidases that collectively are capable of degrading the basement membrane and virtually all other structural components of the extracellular matrix (ECM). The MMPs are produced as inactive precursors containing a secretory signal sequence and a propeptide. Proteolytic cleavage of this propeptide is required for MMP activation. The MMP-9 degrades structural components of ECM and is also involved in the functional regulation of non-ECM molecules, such as TGFb, various cytokines and chemokines, as well as the adhesion receptor ICAM-1. MMP-9 is predominantly expressed by stromal cells, including polymorphonuclear cells and macrophages. Besides being involved in normal tissue morphogenesis and organization, MMP-9 is believed to play a critical role in tumor invasion and metastasis, as well as in angiogenesis. In cancer tissue, stromal cell expression may be induced by tumor cell infiltration, by direct cell-cell contact, in paracrine manner via secretion of tumor-derived factors, or as a result of stimulation by growth factor released from the degraded ECM. MMP-9 expression is increased in almost every type of human cancer, and this correlates, in general, with advanced tumor stage, increased invasion and metastasis, and shortened survival. One exception is colon cancer where the presence of MMP-9-expressing macrophages has been associated with a reduced metastatic proclivity.;Description:Rabbit Anti-Human Matrix Metalloproteinase 9 Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;