Cat#:PA-1367F;Product Name:Rabbit Anti-Human MAPT Antibody;Synonym:MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549; microtubule-associated protein tau; PHF-tau; OTTHUMP00000239567; OTTHUMP00000239568; OTTHUMP00000239569; OTTHUMP00000239570; OTTHUMP00000239571; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1;Background:Tau protein is a microtubule (MT)-associated protein present in brain and other neuronal tissues. It is expressed predominantly in axons of both the central and the peripheral nervous system, but is barely detectable in astrocytes and oligodendrocytes of the central nervous system. In the adult brain, alternative splicing of 3 exons generates 6 tau isoforms ranging from 352 to 441 amino acids in length, however, only the shortest tau isoform is expressed in the fetal brain. Intracellular accumulations of abnormal tau filaments are characteristic in a heterogeneous group of diseases known as neurodegenerative tauopathies; including Alzheimer´s disease. Binding of tau to MTs is related to the degree of phosphorylation, and hyperphosphrylation of tau may lead to disengagement of tau from MTs, thereby increasing the pool of unbound tau which then may aggregate into insoluble filamentous inclusions. The precise mechanisms whereby tau assembles into filaments and causes neurodegeneration in the human brain remain to be elucidated.;Description:Rabbit Anti-Human MAPT Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;