Cat#:PA-1492F;Product Name:Rabbit Anti-Human LEP (amino terminal) Antibody;Synonym:Leptin amino term.; LEP; leptin; OB; OBS; FLJ94114; obese protein; obesity factor; OTTHUMP00000212285; obese, mouse, homolog of;leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEP (amino terminal);Background:This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.;Description:Rabbit Anti-Human LEP (amino terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG2b;Application:IHC, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;