Cat#:PA-1627F;Product Name:Rabbit Anti-Human KIT Antibody;Synonym:PBT; SCFR; C-Kit; CD117; KIT; mast/stem cell growth factor receptor; OTTHUMP00000158901; OTTHUMP00000218587; proto-oncogene c-Kit; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein;Background:The protooncogene c-kit, localized to human chromosome 4, encodes a transmembrane receptor, CD117/c-kit, belonging to the class III receptor tyrosine kinase family, which includes the receptor for colony-stimulating factor 1, and the platelet-derived growth factor receptors type A and B. The extracellular region of these receptors consists of five immunoglobulin-like domains where the second and third loops are thought to be involved in ligand binding. The intracytoplasmic tyrosine kinase domain is split by a long hydrophilic insert between the ATPbinding region and the phosphotransferase active site. Receptor activation is accompanied by receptor dimerization, substrate phosphorylation and autophosphorylation, receptor internalization, activation of protein kinases and phospholipases, and transcription of different protooncogenes. Generally, the c-kit tyrosine kinase receptor pathway has been shown to be important for tumour growth and progression in several cancers and mutations in the c-kit gene leading to ligand-independent phosphorylation (activation) of the c-kit tyrosine kinase, and are believed to have a central pathogenetic role in e.g. gastrointestinal stromal tumours.;Description:Rabbit Anti-Human KIT Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG2a;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;