Cat#:PA-1731F;Product Name:Rabbit Anti-Human IKK complex Associated Protein (IKAP) Antibody;Synonym:inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; FLJ12497; DKFZp781H1425; elongator complex protein 1; p150; OTTHUMP00000021869; IKK complex-associated protein; ikappaB kinase complex-associated protein;Background:IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKKß, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation.;Description:Rabbit Anti-Human IKK complex Associated Protein (IKAP) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:N/A;Application:WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;