Cat#:PA-3602F;Product Name:Rabbit Anti-Human CD3 Antibody;Synonym:4930549J05Rik; A430104F18Rik; AW552088; CD 3; Cd247; CD247 antigen; CD247 antigen, zeta subunit; CD247 molecule; CD3; CD3 delta; CD3 epsilon; CD3 eta; CD3 gamma; CD3 molecule delta polypeptide; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma polypeptide; CD3 zeta; CD3D; CD3D antigen delta polypeptide; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule delta; CD3d molecule delta CD3 TCR complex; CD3d molecule, delta (CD3-TCR complex); CD3E; CD3e antigen; CD3E antigen epsilon polypeptide; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule epsilon; CD3e molecule epsilon CD3 TCR complex; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3G; CD3g antigen; CD3G antigen gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule gamma; CD3g molecule gamma CD3 TCR complex; CD3g molecule, gamma (CD3-TCR complex); CD3H; CD3Q; CD3Z; CD3zeta; Ctg3; FLJ17620; FLJ17664; FLJ18683; FLJ79544; FLJ94613; MGC138597; OKT3, delta chain; OTTHUMP00000032544; T cell receptor; T cell receptor T3 delta chain; T cell receptor T3 gamma chain; T cell receptor T3 zeta chain; T cell receptor zeta chain; T cell surface antigen; T cell surface antigen T3/Leu 4 epsilon chain; T cell surface glycoprotein CD3; T cell surface glycoprotein CD3 delta chain; T cell surface glycoprotein CD3 epsilon chain; T cell surface glycoprotein CD3 gamma chain; T cell surface glycoprotein CD3 zeta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 gamma chain; T3D; T3E; T3G; T3Z; TCRE; TCRk; TCRZ; TCRzeta;Background:CD3 consists of at least four different components (γ,δ,ε,ζ) of 20-28 kDa. On the lymphocyte cell surface, CD3 is non-covalently associated with the T-cell receptor (TCR). It is believed that the CD3 components of the TCR/CD3 complex mediate signal transduction upon antigen recognition by TCR. CD3 is expressed by T cells in thymus, bone marrow, peripheral lymphoid tissue and blood. The only other normal cell type known to be labelled by antibodies to CD3, is Purkinje cells in the cerebellum. The CD3 antigen is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T-cell lineage. In immature thymocytes the CD3 expression is solely cytoplasmic, membrane-associated CD3 appears subsequently upon cell maturation. The majority of T-cell neoplasms express the CD3 antigen, while it is absent from non-T-cell lymphoid malignancies. Consistent with the pattern of synthesis of the antigen in normal thymocytes, the earliest site where CD3 is detectable within neoplastic cells is in the cell cytoplasm. CD3 has been deemed an essential marker for the initial evaluation of chroniclymphoproliferative disorders. Large granular lymphocyte leukaemia of T-cell type (T-LGL) is characterized by the CD3+/CD57+/CD56- immunophenotype and clonal rearrangement of the T-cell receptor genes.;Description:Rabbit Anti-Human CD3 Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;