Cat#:PA-3648F;Product Name:Rabbit Anti-Human CCR5 (N-terminal) Antibody;Synonym:CCR5; chemokine (C-C motif) receptor 5; CKR5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; FLJ78003; C-C chemokine receptor type 5; CCR-5; chemr13; C-C CKR-5; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; AM4 7; CCR5 chemokine (C C motif) receptor 5; CHEMR13; OTTHUMP00000209784; CD195 antigen;Background:This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.;Description:Rabbit Anti-Human CCR5 (N-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Application:WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;