Cat#:PA-3713F;Product Name:Rabbit Anti-Human CALCA Antibody;Synonym:CALCA; calcitonin-related polypeptide alpha; CT; KC; CGRP; CALC1; CGRP1; CGRP-I; MGC126648; calcitonin; katacalcin; calcitonin 1; alpha-type CGRP; OTTHUMP00000216318; OTTHUMP00000216319; OTTHUMP00000216320; OTTHUMP00000216321; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha;Background:Calcitonin (CT) is a 32 amino acid peptide hormone derived from a precursor containing 136 amino acids and an Nterminal leader sequence. CT contains a carboxyterminal proline amide and a disulphide bridge between cysteine residues at position 1 and 7. The sequence is highly conserved in a variety of species within the N-terminal loop region but demonstrates divergence in the rest of the sequence. CT is produced in the parafollicular C-cells of the thyroid and acts through its receptors (CTR) causing osteoclast-mediated bone resorption and calcium excretion by the kidney. Accumulating evidence supports the existence of non-thyroidal CT-like peptides in tissues such as brain, prostate and uterus, which suggest additional physiological roles of CT. Calcitonin is a reliable tumour marker as it is secreted by normal C-cells as well as in MTC. MTC may be sporadic (∼75% of cases) or familial (∼25% of cases), the latter has an autosomal dominant pattern of inheritance.;Description:Rabbit Anti-Human CALCA Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:N/A;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;