Cat#:PA-3741F;Product Name:Rabbit Anti-Human C4c Complement Antibody, FITC-Conjugated;Synonym:Acidic complement C4; Basic complement C4; CH; Chido blood group; Complement component 4A; Complement component 4B; RG; Rodgers blood group; C4A; C4B; complement component 4A (Rodgers blood group); C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; CPAMD2; MGC164979; complement C4-A; acidic C4; C4A anaphylatoxin; OTTHUMP00000029266; OTTHUMP00000216221; Rodgers form of C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2;Background:C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.;Description:Rabbit Anti-Human C4c Complement Polyclonal Antibody, FITC-Conjugated;Host Species:Rabbit;Species Reactivity:Human;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;