Cat#:PA-017F;Product Name:Rabbit Anti-Bovine XDH Antibody;Synonym:XDH; xanthine dehydrogenase; xanthine dehydrogenase/oxidase; XAO; XO;Background:Xanthine oxidase (XO (sometimes 'XAO'), a form of xanthine oxidoreductase that generates reactive oxygen species) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. This enzyme plays an important role in the catabolism of purines in some species, including humans. Xanthine oxidase can be converted to xanthine dehydrogenase by reversible sulfhydryl oxidation. Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). efects in XDH are the cause of xanthinuria type 1 (XU1) [MIM: 278300]. Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol;Description:Rabbit Anti-Bovine XDH Monoclonal Antibody;Host Species:Rabbit;Species Reactivity:virus;Clone#:302;Isotype:N/A;Application:ELISA, IEP;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;