Cat#:PA-279F;Product Name:Mouse Anti-Troponin I, Skeletal Muscle Antibody;Synonym:TNNI2; troponin I type 2 (skeletal, fast); DA2B; FSSV; fsTnI; AMCD2B; troponin I, fast skeletal muscle; OTTHUMP00000014141; OTTHUMP00000014142; OTTHUMP00000014143; troponin I fast twitch 2; troponin I, skeletal, fast; troponin I, fast-twitch isoform; fast-twitch skeletal muscle troponin I; troponin I, fast-twitch skeletal muscle isoform;Background:Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene;Description:Mouse Anti-Troponin I, Skeletal Muscle Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:12F21;Isotype:IgG2b;Application:ELISA, Pr, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;