Cat#:PA-281F;Product Name:Mouse Anti-Troponin C-Cardiac Antibody;Synonym:Cardiac troponin C; CMH7; cTnI; Slow troponin C1; TN C; TNC; TNNC 1; TNNC; TNNC1; TNNC1 protein; TNNI3; Troponin C cardiac; Troponin C slow skeletal and cardiac muscles; Troponin C type 1 (slow); Troponin C type 1; Troponin C1 slow; Troponin I type 3 (cardiac); TN-C; CMD1Z; CMH13; troponin C, slow skeletal and cardiac muscles; troponin C, slow skeletal and cardiac muscles; troponin C1, slow; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; troponin C type 1 (slow); OTTHUMP00000213108; TN-C; TNC; CMD1Z; slow twitch skeletal/cardiac muscle troponin C; CMH13; troponin C, slow skeletal and cardiac muscles; troponin C, slow; troponin C1, slow;Background:Troponin C is a part of the troponin complex. It contains four calcium-binding EF hands. It is a component of thin filaments (along with actin and tropomyosin). It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of TnI. The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of TnI after calcium binding. Troponin C, slow skeletal and cardiac muscles is a protein that in humans is encoded by the TNNC1 gene. Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: TnI which is the inhibitor of actomyosin ATPase, TnT which contains the binding site for tropomyosin and TnC. The binding of calcium to TnC abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium ion uptake by troponin C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension;Description:Mouse Anti-Troponin C-Cardiac Monoclonal Antibody;Host Species:Mouse;Clone#:7C0;Isotype:IgG1;Application:ELISA, Pr, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;