Cat#:PA-373F;Product Name:Mouse Anti-Trefoil Factor 1 Antibody;Synonym:TFF1; trefoil factor 1; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2; gastrointestinal trefoil protein pS2; breast cancer estrogen-inducible sequence; Breast cancer estrogen-inducible protein; breast cancer, estrogen-inducible sequence expressed in gastrointestinal trefoil protein pS2; pS2 protein; trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancer cell line M.;Background:This antibody recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy. Studies have shown that if pS2 staining is observed, ER staining should also be positive; thus pS2 not only has prognostic value, but help guards against ER technical false negatives.;Description:Mouse Anti-Trefoil Factor 1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:pS2.2;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;