Cat#:PA-357F;Product Name:Mouse Anti-Thyroglobulin Antibody;Synonym:TGN; OTTHUMP00000227159; AITD 3; hTG; TDH3; TG; Tgn; Thyroglobulin;Background:Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.;Description:Mouse Anti-Thyroglobulin Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:2H11+6F2;Isotype:IgG1 /IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;