Cat#:PA-3321F;Product Name:Mouse Anti-Rat C-peptide II, N-terminal Antibody;Synonym:Ins1; insulin1;Background:Proinsulin C-peptide was first described in 1967 in connection with the discovery of the insulin biosynthesis. It serves as an important linker between the A- and the B- chains of insulin and facilitates the efficient assembly, folding, and processing of insulin in the endoplasmic reticulum. Equimolar amounts of C-peptide and insulin are then stored in secretory granules of the pancreatic beta cells and both are eventually released to the portal circulation. Initially, the sole interest in C-peptide was as a marker of insulin secretion and has as such been of great value in furthering the understanding of the pathophysiology of type 1 and type 2 diabetes. The first documented use of the C-peptide test was in 1972. During the past decade, however, C-peptide has been found to be a bioactive peptide in its own right, with effects on microvascular blood flow and tissue health.;Description:Mouse Anti-Rat C-peptide II, N-terminal Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Rat;Clone#:B173N;Isotype:IgG1;Application:ELISA, Pr;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;