Cat#:PA-2312F;Product Name:Mouse Anti-Rabbit Light Chain Antibody;Synonym:IgG; Immunoglobulin G; IgG-L; Immunoglobulin G-L; IgG light chain; Immunoglobulin G L chain; Immunoglobulin G Light Chain;Background:The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm. The exact normal ratio of kappa to lambda ranges from 0.26 to 1.65. Both the kappa and the lambda chains can increase proportionately, maintaining a normal ratio. This is usually indicative of something other than a blood cell dyscrasia, such as kidney disease.;Description:Mouse Anti-Rabbit Light Chain Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Rabbit;Application:ELISA, DB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;