Cat#:PA-1267F;Product Name:Mouse Anti-MSH6 Antibody;Synonym:MSH6; mutS homolog 6 (E. coli); p160; GTBP; HNPCC5; MutS-alpha 160 kDa subunit; mutS (E. coli) homolog 6; GTMBP; HSAP; G/T mismatch-binding protein; sperm-associated protein; DNA mismatch repair protein Msh6; hMSH6; OTTHUMP00000159397;Background:This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.;Description:Mouse Anti-MSH6 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:BC/55;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;