Cat#:PA-1599F;Product Name:Mouse Anti-Kininogen Heavy Chain Antibody;Synonym:HMWK light chain; Kininogen 1; Kininogen 1 light chain; KNG; KNG1;Background:Kininogens are inhibitors of thiol proteases. HMW Kininogen plays an important role in blood coagulation by helping to position optimally pre-Kallikrein and Factor XI next to Factor XII. HMW Kininogen inhibits the Thrombin- and Plasmin-induced aggregation of thrombocytes; the active peptide Bradykinin that is released from HMW Kininogen shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis and decrease in blood glucose level. It is also a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation (e.g. Prostaglandins) and it has a cardioprotective effect (directly via Bradykinin action, indirectly via endothelium-derived relaxing factor action).;Description:Mouse Anti-Kininogen Heavy Chain Monoclonal Antibody;Host Species:Mouse;Clone#:2;Isotype:IgG1;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;