Cat#:PA-022F;Product Name:Mouse Anti-Human Wilms Tumor 1 Antibody;Synonym:WT1; Wilms tumor 1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; Wilms tumor protein; OTTHUMP00000037553; OTTHUMP00000037554; OTTHUMP00000037555; OTTHUMP00000037556; OTTHUMP00000238018;Background:WT1 is a gene involved in the induction of Wilms’ tumor, a pediatric renal malignancy. The WT1 gene, located on chromosome 11p13, is inactivated in 5 to 10% of sporadic Wilms’ tumors and nearly 100% of Denys-Drash patients, a syndrome associated with genitourinary abnormalities and Wilms’ tumor. WT1 encodes a zinc finger transcription factor which recognizes the early growth response (EGR-1) consensus sequence found in promoters of growth factor genes. The protein encoded by WT1 regulates transcription of other genes and can function both as a transcriptional activator and repressor. WT1 has been demonstrated to repress transcription of various growth-related genes such as platelet-derived growth factor A chain (PDGF-A) and insulin-like growth factor (IGF). The transcriptional activity of this protein, however, can be modulated through physical interactions between WT1 and p53. In the absence of wild type p53, WT1 has been demonstrated to function as a transcriptional activator of the EGR-1 promoter in transfection assays.;Description:Mouse Anti-Human Wilms Tumor 1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:6F-I3;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;