Cat#:PA-106F;Product Name:Mouse Anti-Human VEGFA Antibody;Synonym:VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; VEGF-A; MGC70609; vascular permeability factor; vascular endothelial growth factor isoform VEGF165; vascular endothelial growth factor; OTTHUMP0000001648; OTTHUMP00000016488; OTTHUMP00000165985; OTTHUMP00000165986; OTTHUMP00000165987; OTTHUMP00000224107; OTTHUMP00000224108; OTTHUMP00000224109; OTTHUMP00000224153; OTTHUMP00000224154; OTTHUMP00000224423; OTTHUMP00000224424; OTTHUMP00000224425; OTTHUMP00000224426; OTTHUMP00000224427; OTTHUMP00000224428; OTTHUMP00000224429; OTTHUMP00000224430;Background:The human VEGFA gene, located on chromosome 6p21.3, contains 8 exons separated by 7 introns. Alternative exon splicing results in generation of 6 different isoforms, VEGF-121, VEGF-145, VEGF-165, VEGF-183, VEGF-189, and VEGF-206, which are named according to the number of amino acids in the peptide chain. Native VEGF protein is a heparin-binding homodimeric glycoprotein of 45 kDa. VEGF-121 is a weakly acidic polypeptide that fails to bind to heparin, while VEGF-165 and VEGF-189 are more basic and bind heparin with increasingly greater affinities. Of these 3 isoforms, VEGF-165 is the predominant molecular form produced in normal cells and tissues. The other isoforms, VEGF-121 and VEGF-189, are detected in the majority of cells and tissues that express the VEGF gene.;Description:Mouse Anti-Human VEGFA Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:VH2;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;
The human VEGFA gene, located on chromosome 6p21.3, contains 8 exons separated by 7 introns. Alternative exon splicing results in generation of 6 different isoforms, VEGF-121, VEGF-145, VEGF-165, VEGF-183, VEGF-189, and VEGF-206, which are named according to the number of amino acids in the peptide chain. Native VEGF protein is a heparin-binding homodimeric glycoprotein of 45 kDa. VEGF-121 is a weakly acidic polypeptide that fails to bind to heparin, while VEGF-165 and VEGF-189 are more basic and bind heparin with increasingly greater affinities. Of these 3 isoforms, VEGF-165 is the predominant molecular form produced in normal cells and tissues. The other isoforms, VEGF-121 and VEGF-189, are detected in the majority of cells and tissues that express the VEGF gene.
Description:
Mouse Anti-Human VEGFA Monoclonal Antibody
Host Species:
Mouse
Species Reactivity:
Human
Clone#:
VH2
Isotype:
IgG1, kappa
Application:
IHC
Usage:
For Lab Research Use Only
Storage:
Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles