Cat#:PA-147F;Product Name:Mouse Anti-Human TYR Antibody;Synonym:TYR; CMM8; OCA1A; OCAIA; SHEP3; tyrosinase; SK29-AB; LB24-AB; monophenol monooxygenase; tumor rejection antigen AB; tyrosinase (oculocutaneous albinism IA); EC 1.14.18.1;Background:Tyrosinase is a copper-glycoenzyme involved in the production of melanin pigments, including both eumelanin and pheomelanin. In this process tyrosinase catalyzes the hydroxylation of L-tyrosine to L-dopa and the oxidation of L-dopa to L-dopaquinone. As a marker of melanocytic lineage, tyrosinase is localized to melanocytes which can be found on the dermal/epidermal junction of normal skin, but is not detected in other normal cells. Pigmented parts of the eye such as the choroid and iris also contain melanocytes. Expression of tyrosinase is also found in melanocytic lesions including benign nevi and the majority of primary and metastatic malignant melanomas, and not in nonmelanocytic tumor types.Additionally, tyrosinase can be recognized by autologous cytotoxic T-cells from melanoma patients, and therefore tyrosinase peptides have utility in melanoma vaccines.;Description:Mouse Anti-Human TYR Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:T322;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;