Cat#:PA-217F;Product Name:Mouse Anti-Human TPSAB1 Antibody;Synonym:alpha II; EC 3.4.21.59; Lung tryptase; Mast cell protease 7; Mast cell protease II; MMCP 7; Pituitary tryptase; Skin tryptase; TPS 1; TPS1; TPS2; TPSAB1; TPSAB1 protein; TPSB1; Tryptase 1; Tryptase alpha 1; tryptase alpha I included; tryptase alpha II included; tryptase alpha included; tryptase alpha/beta 1; Tryptase beta 1; tryptase beta I included; Tryptase I; tryptase I included; Tryptase skin; Tryptase-1; EC 3.4.21; MGC104064; tryptase alpha/beta-1; tryptase-1; tryptase-I; tryptase-III; tryptase beta I; tryptase beta-1; tryptase alpha-1; tryptase alpha II; OTTHUMP00000115530; OTTHUMP00000213242; mast cell beta I tryptase; mast cell alpha II tryptase;Background:Human mast cell tryptases (EC 3.4.21.59) comprise a family of trypsin-like neutral serine proteases that are predominantly expressed in mast cells. In its enzymatically active form, mast cell tryptase exists as a non-covalently linked tetramer of 132 kDa. Mast cell tryptase is capable of degrading vasoactive intestinal peptide and activating prekallikrein as well as generating kinins, all important mediators involved in bronchoconstriction and airway hyperresponsiveness, which are major contributors to allergic airway disease. Mast cell tryptase also exhibits mitogenic effect on human airway smooth muscle cells, and human lung and dermal fibroblasts. Both smooth muscle hyperplasia and fibrotic changes can lead to thickening of the airway wall and a permanent reduction in airway calibre. Mast cells are activated by a number of stimuli, including antigen, superoxides, complement protein, neuropeptides and lipoproteins, resulting in activation and degranulation. Mast cell degranulation and thereby release of mast cell tryptase as well as histamine, leukotrienes and cytokines into the surrounding tissue is a pivotal event in an inflammatory response and seems to play an important role in host defense against pathogens (4). Mast cells play an active role in such diverse diseases as atherosclerosis, asthma, arthritis, bile duct fibrosis, malignancy and pulmonary fibrosis.Identification of mast cells through staining of tissues with antibodies specific for human mast cell tryptase has been useful in identification of focal and diffuse MC infiltrates in primary MC disease and mastocytosis. Demonstration of mast cell tryptase is essential for the identification of highly atypical, hypogranulated or even non-metachromatic MCs, especially in MC leukaemia, and for the detection of small or minute MC infiltrates.;Description:Mouse Anti-Human TPSAB1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:AB2;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;