Cat#:PA-346F;Product Name:Mouse Anti-Human Thrombomodulin Antibody;Synonym:THBD; thrombomodulin; TM; THRM; AHUS6; CD141; fetomodulin; CD141 antigen; BDCA3; OTTHUMP00000030415;Background:Thrombomodulin (TM) was recently reviewed and described to be a trans-membrane glycoprotein of MW 75 kD which contains six repeated domains homologous with epidermal growth factor (EGF) and an amino terminal domain homologous to lectin-like proteins. Through its accelerated activation of protein C (which in turn acts as an anticoagulant by binding protein S and thrombin), synthesis of TM is one of several mechanisms important in maintaining thrombo-resistance and thus reducing clot formation on the surface of the endothelial cells. TM expression is up-regulated by agents which increase cAMP and down-regulated by interleukin I, TNF and certain endotoxins.;Description:Mouse Anti-Human Thrombomodulin Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:1010;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;