Cat#:PA-751F;Product Name:Mouse Anti-Human PTPRC Antibody, APC-Conjugated;Synonym:PTPRC; protein tyrosine phosphatase, receptor type, C; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; OTTHUMP00000033813; OTTHUMP00000033816; OTTHUMP00000033817; OTTHUMP00000038574; leukocyte common antigen; leukocyte-common antigen; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; EC=3.1.3.48;Background:CD45 is a single-chain type I transmembrane protein typically expressed at high levels on all nucleated cells of haematopoietic origin. Thus, CD45 is present on T and B-lymphocytes, granulocytes, monocytes and macrophages, with the exception of maturing erythrocytes and megakaryocytes. There are five different isoforms of CD45, based on differential splicing of exons 4, 5 and 6, named ABC, AB, BC, B and 0. The Mr of the isoforms ranges from 220 000 for the ABC isoform to 180 000 for the 0 isoform. All the CD45 isoforms share the same intracellular segment which has been shown to have tyrosine phosphatase activity and which has a functional role in lymphocyte activation and differentiation. Antibodies that recognize all five isoforms are known as anti-CD45.;Description:Mouse Anti-Human PTPRC Monoclonal Antibody, APC-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:T29/44;Isotype:IgG1, kappa.;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;