Cat#:PA-787F;Product Name:Mouse Anti-Human proteinase 3 Antibody;Synonym:MBN; MBT; NP4; P29; PR3; ACPA; AGP7; PR-3; CANCA; C-ANCA; myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen; proteinase 3; NP-4; AGP7; PR3; P29; C-ANCA antigen; PR-3; CANCA; ACPA; NP4; C-ANCA; azurophil granule protein 7; MBT; myeloblastin; Leukocyte proteinase 3; serine proteinase, neutrophil; Neutrophil proteinase 4; Wegener granulomatosis autoantigen; Wegener autoantigen; EC 3.4.21.76; MBN; EC 3.4.21;Background:PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.;Description:Mouse Anti-Human proteinase 3 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:1F21;Isotype:IgG2b;Application:ELISA, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;