Cat#:PA-2821F;Product Name:Mouse Anti-Human Prostate Specific Membrane Antigen (PSMA) Antibody;Synonym:FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; OTTHUMP00000233840; OTTHUMP00000233843; OTTHUMP00000233844; folate hydrolase 1; glutamate carboxylase II; cell growth-inhibiting protein 27; prostate-specific membrane antigen; membrane glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase;Background:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.;Description:Mouse Anti-Human Prostate Specific Membrane Antigen (PSMA) Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:B792N;Isotype:IgG2b;Application:ELISA;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;