Cat#:PA-855F;Product Name:Mouse Anti-Human PMEL Antibody;Synonym:mel17; silver homolog (mouse); 95 kDa melanocyte specific secreted glycoprotein; 95 kDa melanocyte-specific secreted glycoprotein; D12S53E; gp100; M-beta; ME20; ME20 M/ME20 S; ME20-M; ME20-S; ME20M; ME20M/ME20S; ME20S; Melanocyte lineage specific antigen GP100; Melanocyte protein mel 17; Melanocyte protein Pmel 17; Melanocyte protein Pmel 17 precursor; Melanocytes lineage-specific antigen GP100; Melanoma associated ME20 antigen; Melanoma-associated ME20 antigen; Melanosomal matrix protein 17; Melanosomal matrix protein17; P1; p100; p26; PMEL 17; PMEL; PMEL_HUMAN; PMEL17; Premelanosome protein; Secreted melanoma-associated ME20 antigen; SI; SIL; SILV; Silver (mouse homolog) like; Silver homolog; Silver locus protein homolog; Silver, mouse, homolog of; melanocyte protein PMEL; Human Melanosome;Background:The presence of the IMB46 antigen indicates active melanosome formation and thus melanocytic differentiation. It is also expressed in normal fetal melanocytes, but not in normal resting adult melanocytes, regardless of the degree of pigmentation. Upon activation, adult melanocytes can re-express the IMB46-defined antigen (as it is expressed in fetal melanocytes). Such melanocytes are activated by a variety of stimuli. For example, IMB46-positive cells have been detected in tissue overlying or adjacent to granulation tissue, hemangiomas, vessel-rich tumor stroma, and basal cell carcinoma. Hair follicles stain occasionally due to associated stimulated melanocytes. Positive IMB46 staining has not been observed with melanocytes in lentigines or overlying fibroblastic proliferations such as keloids, dermatofibromas and old fibrotic hemangiomas. Non-melanocytic normal tissues do not react with the IMB46 antibody.;Description:Mouse Anti-Human PMEL Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:HMB-56;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;