Cat#:PA-1125F;Product Name:Mouse Anti-Human NPM1 Antibody;Synonym:NPM1; nucleophosmin (nucleolar phosphoprotein B23, numatrin); B23; NPM; MGC104254; nucleophosmin; numatrin; OTTHUMP00000161024; OTTHUMP00000161025; OTTHUMP00000223397; OTTHUMP00000223398; nucleolar protein NO38; nucleophosmin/nucleoplasmin family, member 1;Background:Nucleophosmin (NPM) is a phosphoprotein belonging to the protein family of nucleoplasmins. NPM is predominantly localized in thenucleus of cells in many tissues. However, NPM has the ability to shuttle between the nucleus and cytoplasm, and this shuttling activityand its proper subcellular localization might be crucial for cellular homeostasis. The NPM gene (NPM1) is frequently overexpressed, mutated, deleted or rearranged in many human malignancies, and, depending on its expression level and gene dosage, NPM seems tofunction as either an oncogene or a tumor suppressor. Complete functional loss of NPM leads to aneuploidy and activation of cellproliferation checkpoints.Mutations in exon 12 of the NPM1 gene is causal for generation of a mutant NPM counterpart, NPMc, which is aberrantly localized in thecytoplasm of leukaemic blasts cell in a large subgroup of primary acute myeloid leukemia (AML) cases with a normal karyotype.NPMc display a multilineage distribution in AML specimens of all subtypes except M3 (acute promyelocytic leukemia), M4eo (acutemyelomonocytic leukemia with eosinophilia) and M7 (acute megakaryocytic leukemia). It is likely that mutation and cytoplasmicaccumulation of NPMc, called NPMc+, is a primary leukemogenic event, as it may interfere with the normal NPM function. NPMc is notobserved in any primary AML cases with a specific genetic abnormality, in secondary AML specimens or hematopoietic orextrahematopoietic neoplasms other than AML. NPMc is only observed in primary AML with a normal karyotype.;Description:Mouse Anti-Human NPM1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:387;Isotype:IgG1, lambda;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;