Cat#:PA-1605F;Product Name:Mouse Anti-Human KLK3 Antibody;Synonym:APS; PSA; hK3; KLK2A1; KLK3; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3;Background:Prostate-Specific Antigen (PSA) is a 33 kDa protein belonging to the kallikrein family of proteases. It is primarily produced by the prostatic epithelium and the epithelial lining of the periurethal glands, and is secreted at concentrations of 0.5-2 g/L into the seminal fluid, where it liquefies the gel forming after ejaculation by digesting the major gel-forming proteins. Five to six isoenzymes of PSA can be separated from seminal fluid by isoelectric focusing and ion exchange chromatography (4). From the normal and hyperplastic prostate, PSA leaks into the extracellular fluid and diffuses into the blood, where the concentration is approximately one million-fold lower than in seminal fluid. In prostate cancer, the architecture and polarization of the epithelial cells are deranged, leading to active secretion into the extracellular space and into the circulation, and causing increased serum PSA concentrations. PSA is strongly expressed in both normal and neoplastic prostatic tissue. Although PSA can be considered prostate-specific, PSA and/or PSA gene expression has been detected at low levels in some extraprostatic tissues such as normal breast tissue, breast tumours, breast milk, female serum, endometrium, adrenal neoplasms and renal cell carcinomas.;Description:Mouse Anti-Human KLK3 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:ER-PS9;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;