Cat#:PA-1657F;Product Name:Mouse Anti-Human ITGAM Integrin, Alpha M Antibody, RPE-Conjugated;Synonym:CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; MGC117044; integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit; CD11b; CD11b antigen;Background:The CD11b antigen is the 165 kDa α-chain of the Mac-1 complex. The molecule, also called CR3, functions as a cell surface receptor for the C3bi complement fragment. There is evidence that CD11b can bind fibrinogen in addition to C3bi. Two binding sites have now been reported, one recognizing lipopolysaccharide, and the other protein ligands containing the arg-gly-asp sequence. Binding of the coagulation factor X has also been suggested as an additional receptor role of CD11b. This protein belongs to a family of related heterodimeric proteins designated CD11 in the classification system for human leucocyte differentiation antigens, which shares a common β-chain with a MW of 95 kDa (CD18). Besides the C3bi receptor, this protein family contains two other members, leucocyte function associated-1 (LFA-1, CD11a) antigen and p150, 95 protein (CD11c). Each of the three CD11 α-chains are encoded by genes which cluster on the short arm of chromosome 16 between bands p11 and p13.1. The β-chain is encoded on chromosome 21 at band q22. Each of the three members of the CD11/CD18 family appears to play a role in adhesion of leucocytes to vascular endothelium. However, the interaction between these molecules and other cell types is complex and may involve more than a single receptor. The three members are part of the integrins which constitute a family of related membrane receptors in cell-cell and cell-matrix interactions.;Description:Mouse Anti-Human ITGAM Integrin, Alpha M Monoclonal Antibody, RPE-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:2LPM10d;Isotype:IgG1, kappa;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;