Cat#:PA-1680F;Product Name:Mouse Anti-Human IRF4 Antibody;Synonym:IRF4; MUM1; LSIRF; interferon regulatory factor 4; IRF-4; NF-EM5; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; OTTHUMP00000017905; OTTHUMP00000017906;Background:MUM1 protein (multiple myeloma oncogene-1) is a 50 kDa protein encoded by the MUM1 gene that was originally identified because of its involvement in the rare t(6;14)(p25;q32) translocation observed in multiple myeloma (MM), causing juxtaposition of the MUM1 gene to the Ig heavy chain locus. MUM1-protein-deficient mice are unableto form germinal centres, lack plasma cells in the spleen and lamina propria, and exhibit a profound reduction of serum immunoglobulin levels and an inability to mountdetectable antibody responses or to generate T-lymphocyte cytotoxic or antitumour responses. Expression of MUM1 protein is independent from the t(6;14) (p25;q32)translocation and has been detected in multiple myelomas, lymphoplasmacytic lymphomas (LPL), diffuse large B-cell lymphomas (DLBCL), and activated T cells. MUM1 proteinis not specific for plasmacytic differentiation, but it may be added to the panel of phenotypic markers available for characterization of B-cell lymphoma histogenesis, in additionto being a useful marker in the subclassification of lymphoid malignancies, e.g. in B-CLL.MUM1 protein expression is restricted to cells in the lymphocytic and melanocytic lineages.;Description:Mouse Anti-Human IRF4 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:MUM2q;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;