Cat#:PA-2214F;Product Name:Mouse Anti-Human IgA1 Antibody;Synonym:Ig alpha 1 chain C region; IGHA1; immunoglobulin heavy constant alpha 1; IgA1; Immunoglobulin A1; IgA1 α1; Immunoglobulin A1 α1; IgA1 heavy chain; Immunoglobulin A1 heavy chain; IgA1 α1 heavy chain; Immunoglobulin A1 α1 heavy chain; IgA1, Fc portion of α1 heavy chain; Immunoglobulin A1, Fc portion of α1 heavy chain; IgA1, Fc; Immunoglobulin A1, Fc;Background:Immunoglobulin A (IgA) is an antibody that plays a critical role in mucosal immunity. More IgA is produced in mucosal linings than all other types of antibody combined; between three and five grams are secreted into the intestinal lumen each day. This accumulates to 75% of the total immunoglobulin produced in the entire body. IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). In its secretory form, IgA is the main immunoglobulin found in mucous secretions, including tears, saliva, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood. The secretory component of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes, thus sIgA can survive in the harsh gastrointestinal tract environment and provide protection against microbes that multiply in body secretions. IgA is a poor activator of the complement system, and opsonises only weakly. Its heavy chains are of the type α.;Description:Mouse Anti-Human IgA1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Application:ELISA, WB, DB, IHC, ICC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;