Cat#:PA-2467F;Product Name:Mouse Anti-Human HLA-DR Antigen, Alpha-Chain Antibody;Synonym:DR alpha chain precursor; HLA class II histocompatibility antigen DR alpha chain; HLA DRA; HLA DRA1; HLADRA1; HLA-DRA; Major histocompatibility complex class II DR alpha; major histocompatibility complex, class II, DR alpha; MLRW; FLJ51114; HLA-DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC cell surface glycoprotein; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; histocompatibility antigen HLA-DR alpha; HLA-DR Antigen, Alpha-Chain;Background:The major histocompatibility complex (MHC), is also known as human leukocyte antigen (HLA). The main function of HLA is to present antigenic peptides to the T cell receptor regulating the immune response. In human, three classes of MHC molecules (I, II and III) have been denoted. Human class II genes are encoded in the HLA-D region, consisting of three families called DQ, DP and DR. The products of class II genes form a heterodimeric transmembrane protein consisting of a heavy (33-35 kDa) α-chain and a light (28-30 kDa) β-chain. The DR α-chain is expressed from one non-polymorphic (monomorphic) gene, and the DR β-chain originates from nine highly polymorphic genes. HLA-D molecules are expressed on dendritic cells, B cells, monocytes, macrophages, myeloid and erythroid precursors and some epithelial cells. HLA-D is expressed on activated T cells. Aberrant expression of Class II antigen in various malignant cell types has been demonstrated.;Description:Mouse Anti-Human HLA-DR Antigen, Alpha-Chain Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:TAL.1C6;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;