Cat#:PA-2479F;Product Name:Mouse Anti-Human HLA-DP, DQ, DR Antigen Antibody;Synonym:CD; CELIAC 1; CELIAC1; DPB1; DQ A1; DRB1; DRB4; FLJ27088; FLJ27328; GSE; HLA class II histocompatibility antigen DR 1 beta; HLA class II histocompatibility antigen DR alpha; HLA class II histocompatibility antigen DR alpha chain; HLA DP histocompatibility type beta 1 subunit; HLA DP1B; HLA DPB1; HLA DQA; HLA DQA1; HLA DQB; HLA DQB1; HLA DR1B; HLA DR3B; HLA DR4B; HLA DRA; HLA DRA1; HLA DRB1; HLA DRB3; HLA DRB4; HLA DRB5; IDDM 1; IDDM1; Major histocompatibility complex class II DP beta 1; Major histocompatibility complex class II DQ alpha 1; Major histocompatibility complex class II DQ beta 1; Major histocompatibility complex class II DR alpha; Major histocompatibility complex class II DR beta 1; Major histocompatibility complex class II DR beta 3; Major histocompatibility complex class II DR beta 4; Major histocompatibility complex class II DR beta 5; MGC117330; MHC class II antigen DRA; MHC class II HLA DQ alpha 1; MHC class II HLA DR beta 1; MHC class II HLA DR beta 3; MHC DPB1; MHC DQ beta; MHC HLA DPB1; MHC HLA DQ alpha; HLA-DP, DQ, DR Antigen;Background:The human leucocyte antigen (HLA) system, originally discovered as the result of a transfusion reaction, is now known to play a crucial role in many areas of clinical medicine. The main function of the HLA-DP, DQ and DR molecules is to present antigenic peptides, mostly of exogenous nature, to CD4+ T-cells. HLA molecules are also known to be associated with a variety of autoimmune, non-autoimmune and infectious diseases and to restrict the antibody response to certain antigens and vaccines. The HLA molecules are encoded by a cluster of tightly linked genes located on the short arm of chromosome 6. Based on some of the structural and functional characteristics of the genes, the region has been divided into three: HLA class I, Class II and class III regions. The Class II HLA-DP, DQ and DR, A and B genes encode a heterodimer formed by two non-covalently associated α and β chains of approximately 34 and 28 kDa respectively. The expressed α and β chains consists of four domains: two extracellular, two intracellular one transmembrane and one cytoplasmic. HLA-DP, DQ and DR molecules are constitutively expressed on antigen-presenting cells such as B lymphocytes, monocytes and dendritic cells but can also be detected on cytototoxic/suppressor T lymphocytes and activated granulocytes. It is uncertain whether HLA-DP, DQ and DR antigens are also expressed on activated platelets. HLA class II expression can also be induced on cells and tissues such as fibroblasts and endothelial cells as a result of activation and/or by certain cytokines such as γ-interferon, tumor necrosis factor and interleukin-10. The antigen has been found on the cell surface of leukaemic blasts from cases of B-cell acute lymphoblastic leukaemia (ALL), T-cell pre-ALL, acute myeloid leukaemia (AML) except AML-M3, and chronic B and T cell leukaemia, chronic myeloid leukaemia (CML) in blast crisis and lymphomas of B cell and T cell type. HLA-DP, DQ, DR antigen is normally not present on non-haematopoietic tumors and multiple myeloma.;Description:Mouse Anti-Human HLA-DP, DQ, DR Antigen Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:CR3/54;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;