Cat#:PA-2482F;Product Name:Mouse Anti-Human HLA-ABC Antigen Antibody;Synonym:HLA A; HLA B; HLA C; HLA class 1 A; HLA class 1 B; HLA class 1 C; Major histocompatibility complex, class I, A + B + C; MHC class I HLA A; MHC class I HLA B; MHC class I HLA C; MHC HLA ABC; HLA-ABC Antigen;Background:HLA class I antigens, HLA-A, -B and -C are widely distributed on most of the human nucleated cells. However, the intensity of expression varies considerably, some cells being only weakly positive, e.g. thyroid and muscle cells, and others negative, e.g. cells of the exocrine pancreas and villous trophoblast cells. The intensity of HLA-ABC may also be altered in pathological states. It has been described that malignant cells may loose HLA-ABC, whereas hepatocytes in alcoholic hepatitis, biliary cirrhosis and chronic active hepatitis express HLA-ABC, in contrast to normal liver hepatocytes on which HLA-ABC was not detected. Increased HLA-ABC expression has been observed in muscle fibres affected by muscular dystrophy, inflammatory myopathy and other neuromuscular disorders.;Description:Mouse Anti-Human HLA-ABC Antigen Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:W6/43;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;