Cat#:PA-2474F;Product Name:Mouse Anti-Human HLA, Class II Antigen-DR+DP Antibody;Synonym:HLA class II histocompatibility antigen DP(W4) beta chain precursor; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN DR ALPHA CHAIN PRECURSOR; HLA DP; HLA DR; HLA-DP1B; HLA-DRA1; MHC Class II; major histocompatibility complex class II DP beta 1; major histocompatibility complex class II DR alpha; MHC class II antigen DRA; HLA, Class II-DR+DP; HLA, Class II Antigen-DR+DP;Background:Human MHC class II antigens are transmembrane glycoproteins composed of an alpha (36 kDa) and a beta chain (27kDa) and are expressed primarily on antigen presenting cells. Human MHC class II genes are located in the HLA-D region that encodes at least 6 alpha and 10 beta chain genes. Three loci, DR, DQ and DP, encode the major products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells and therefore have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.;Description:Mouse Anti-Human HLA, Class II Antigen-DR+DP Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:236-14251;Isotype:IgG2a;Application:FCM, IP;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;