Cat#:PA-3011F;Product Name:Mouse Anti-Human Factor XII Antibody;Synonym:F12; HAF; HAE3; HAEX; coagulation factor XII; Hageman factor; OTTHUMP00000223845; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain;Background:Coagulation factor XII also known as Hageman factor is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene. Factor XII is part of the coagulation cascade and activates factor XI and prekallikrein. Factor XII itself is activated to factor XIIa by negatively charged surfaces, such as glass. In vivo, factor XII is activated by contact to polyanions. Activated platelets secrete inorganic polymers, polyphosphates. Contact to polyphosphates activates factor XII and initiates fibrin formation by the intrinsic pathway of coagulation with critical importance for thrombus formation.Targeting polyphosphates with phosphatases interfered with procoagulant activity of activated platelets and blocked platelet-induced thrombosis in mice. Addition of polyphosphates restored defective plasma clotting of Hermansky-Pudlak syndrome patients, indicating that the inorganic polymer is the endogenous factor XII activator in vivo. Platelet polyphosphate-driven factor XII activation provides the link from primary hemostasis (formation of a platelet plug) with secondary hemostasis (fibrin meshwork formation).;Description:Mouse Anti-Human Factor XII Monoclonal Antibody;Host Species:Mouse;Species Reactivity:human;Clone#:AHXII-5166;Isotype:IgG1;Application:WB, ELA, purification;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;