Cat#:PA-3013F;Product Name:Mouse Anti-Human Factor XI Antibody;Synonym:F11; FXI; MGC141891; coagulation factor XI; PTA; OTTHUMP00000197033; plasma thromboplastin antecedent;Background:Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.;Description:Mouse Anti-Human Factor XI Monoclonal Antibody;Host Species:Mouse;Species Reactivity:human;Clone#:AHXI-5072;Isotype:IgG;Application:RIA, WB, ELA, purification;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;