Cat#:PA-2958F;Product Name:Mouse Anti-Human Factor VII Antibody;Synonym:F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; Eptacog alfa; FVII coagulation protein; Serum prothrombin conversion accelerator; proconvertin; SPCA; EC 3.4.21.21; EC 3.4.21; OTTHUMP00000018733; OTTHUMP00000018734;Background:Factor VII (formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme (EC 3.4.21.21) of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog alfa [activated]) has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients. It is often used unlicensed in severe uncontrollable bleeding, although there has been safety concerns. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy;Description:Mouse Anti-Human Factor VII Monoclonal Antibody;Host Species:Mouse;Species Reactivity:human;Clone#:AHVII-5042;Isotype:IgG1;Application:RIA, WB, ELA, purification;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;