Cat#:PA-2941F;Product Name:Mouse Anti-Human F8 Antibody;Synonym:AHF; F8B; F8C; HEMA; FVIII; DXS1253E; F8; coagulation factor VIII; factor VIII F8B; OTTHUMP00000024269; OTTHUMP00000196174; antihemophilic factor; coagulation factor VIIIc; coagulation factor VIII, procoagulant component; factor VIII F8B; hemophilia A;Background:Factor VIII (FVIII) is an essential blood clotting factor also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a well known recessive X-linked coagulation disorder. Factor VIII participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids forms a complex that converts factor X to the activated form Xa. The Factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Patients with high levels of Factor VIII are at increased risk for deep venous thrombosis and pulmonary embolism.;Description:Mouse Anti-Human F8 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:116;Isotype:IgG2a;Application:ELISA;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;